Human Genetics and Genomics- Nonallele-specific Silencing of Mutant and Wild-type Huntingtin Demonstrates Therapeutic Efficacy in Huntington’s Disease Mice Huntington`s Disease (HD) is an autosomal dominant neurodegenerative disease affecting 4-to-7 per 100,000 individuals. It is classed as a trinucleotide repeat disorder (Marcy et al, 1993) due to the fact that it results from an expanded CAG repeat which leads to a...
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Learning objectives: On completion of this case study, the student/reader will be able to: Describe the etiology of Streptococcus pneumonia infection. Explain the clinical manifestations of Streptococcus pneumonia infections. Identify available treatment options and interventions to prevent Streptococcus pneumonia. History: A 54-year-old white male was seen in the emergency department. He gave a history of homelessness and chronic alcoholism. His...
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Drug addiction has been an ongoing crisis across the country for several years, but especially in New Hampshire, where drug abuse statistics have been on the rise since 2010. Drug abuse is prevalent across all socioeconomic groups, but many New Hampshire residents are unable to afford treatment. In order to address the issues New Hampshire’s residents are facing, New Hampshire...
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Introduction Huntington's Disease (HD) is a progressive neurodegenerative disorder characterized by motor dysfunction, cognitive decline, and psychiatric symptoms. My personal experience with HD, whether through direct acquaintance or academic exploration, provided profound insights into the complexities and challenges associated with this condition. Understanding Huntington's Disease not only demands a grasp of the scientific aspects but also requires empathy and reflection...
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Introduction Drug addiction is a multifaceted issue that has garnered significant attention from both medical professionals and policymakers worldwide. The rise in addiction rates, alongside the devastating social and economic impacts, necessitates a comprehensive understanding of the contributing factors. This paper aims to critically analyze the various elements that lead to drug addiction, emphasizing biological, psychological, and social influences. By...
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The Sri Lankan Army (SLA) is the oldest and biggest organization of the Sri Lankan military and established in 1949 as the Ceylon Army, modified its name when Sri Lanka became a republic in 1972. The Sri Lankan Armed Forces are the unified forces of the Democratic Socialist Republic of Sri Lanka, including Sri Lankan Army, Sri Lankan Navy and...
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Introduction/Statement of the problem Rubella (measles) is a multisystem, human-exclusive virus that has been determined eradicated in the United States since the 1960s. Measles is highly contagious, dealt with public health officials vaccinating nearly the entire population. However, the virus is prevalent in developing and developed regions alike today. Rubeola is an enveloped, single-stranded, negative-sense RNA virus (sense” describing polarity...
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Introduction In the rapidly evolving field of healthcare, alternative therapies are gaining traction as viable complements or alternatives to conventional medical treatments. With the increasing emphasis on personalized medicine, alternative treatments such as acupuncture, herbal medicine, and mindfulness-based therapies are being explored for their potential benefits. These therapies offer holistic approaches that focus on the individual's physical, mental, and emotional...
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In a world where human rights for every person are being discussed and fought for, whether it be a movement for women’s rights, rights for fathers or the LGBT community – this is all becoming normal in society – but what exactly is normal? Normalcy, like many things in the world is misunderstood – some may believe their traditions, values...
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Kentucky S.B. 250: An ACT Relating to Screening for Hepatitis C Hepatitis C (HCV) is a chronic infection that attacks the liver and if not treated liver failure, cancer, and/or death can be the result. This infection is spread through contact with contaminated/infected blood and most individuals that are carriers of Hepatitis C have no symptoms. Typically, we know the...
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Combating Gangs Today, fighting back against juvenile gangs proves to be a strenuous task in which it takes willful individuals to stand up to. The G.R.E.A.T program or Gang Resistance Education and Training Program, established in 1991 appears to be one the most effective ways to deter delinquents against gangs (Lab & Whitehead, 133). In researching, a lot of charismatic...
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Aim/Rationale We as students go through many phases in our lives, some being times of joy, times of sadness and a lot more. But today’s generation Z, is mostly filled with times of depression with one of the main reasons being the competition levels in studies, these experiments being done on students leads us, into stress as the rule “Life...
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Abstract The current trend is residential proximity of industrial and urban sites being a risk factor in causing leukemia. Although there are many risk factors that cause leukemia, the role of industrial and urban pollution needs to be assessed. People need to be aware of every possible risk factor in causing cancer. The study done is a population-based control study....
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A vaccine is defined as a harmless derivative of a pathogen that triggers the body’s immune system response to act against the harmful pathogen. The history of the development of modern vaccines stems from the ground-breaking research undertaken by Edward Jenner, now more famously known as the father of immunology. His revolutionary and pivotal discovery of the smallpox vaccination laid...
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Death of Dissent What it takes to raise a dissent? What is it that you feel so strong within, that you raise a dissent? Well, knock your sleeping conscious and ask “Do I agree”? “Do I accept”? If your conscious says “NO” well then, that is your dissent. Dissent is the inner voice within you that often coerces the logical...
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Background: Dengue Hemorrhagic Fever continues to occur, including in Sorong City, which in the last three years (2016-2018) has experienced improvements that are influenced by the physical environment, social environment, knowledge, attitude, action, occupancy density and health services. Objective: To determine the risk factors for the incidence of Dengue Hemorrhagic Fever in Sorong City, West Papua Province. Research Method: observational...
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A nursing care plan allows a nurse to identify the most pressing concerns for a client, develop nursing interventions and evaluate them. This report details a nursing care plan for a client with liver cirrhosis presenting with unresolved chronic sciatic pain. My client D.R was a gentleman who presented with this disease. He is 75 years old and quite sharp...
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Imagine forty or seventy years from now, you’re in a beautiful home that you built for you and your family. Then your children and grandchildren try to convince you to go to a nursing home saying it’s better for you and you’d be taken care of better. It’s like a slap to the face, it hurts. Your own children that...
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Post Traumatic Stress Disorder affects millions of people every day. It can affect everyone and anyone and they don’t have to have served time in the military. It can be a man, women, child, or elderly. In this paper, I will be going over the definition of PTSD, the classic symptoms, risk factors and causes, prevention methods, warning signs, treatments,...
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Abstract The study assessed the effectiveness of demonstration, discussion and recitation teaching methods on knowledge and practice of food hygiene among almajirai in tsangaya in Kano Municipal, Nigeria. A quasi-experimental design was adopted for the study. A sample of 147 participants was drawn using a multi-stage sampling procedure. Participants were assigned to three groups and lesson on food hygiene was...
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Introduction Lysergic acid diethylamide (LSD) was first synthesized in 1938 by Albert Hofmann (Passie, Halpern, Stichtenoth, Emrich, & Hintzen, 2008). It is a prototypical hallucinogen and has one of the most potent hallucinogenic effects (Wacker et al., 2017). LSD is derived from lysergic acid and there are four optically-active isomers known (Passie et al., 2008). Out of four isomers, d-...
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Introduction The aim of this essay is to explore key concepts impacting on mental health issues and their support. It will start by giving a brief history of the evolution of mental health and its definition. It will explore the definition of theory as well as nursing theory. Once these have been explained two theories will be looked at one...
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Introduction Muscular dystrophy is a group of genetic disorders characterized by muscle weakness. Under normal conditions, muscle requires a precise equilibrium of strength and stability: strength for resistance to mechanical stress and internal tension caused by muscle contraction, and muscular stability for preserving shape, content, and function. Dystrophin, an intracellular protein, maintains muscle integrity. In skeletal muscle, the dystrophin-glycoprotein complex...
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Context Hepatitis C is a contagious disease caused by the HCV virus. It is one of the main causes of chronic liver disease and cirrhosis worldwide, resulting in a large proportion of all liver transplants in the United States, Australia & most of Europe. Hepatitis C was first isolated from non-A, non-B Hepatitis in 1989 and accounts for 90% of...
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At first, you feel nothing. As the tablet dissolves, reality does as well. You look around the room. The room is spinning almost pulsating. It’s as if the world is breathing. It all started by taking a small tablet. This tablet is a form of Lysergic acid diethylamide (LSD). LSD is a widely used drug that has affected various people...
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Case Study: CVA A Cerebrovascular accident (stroke) is a rapid-onset medical emergency than can cause neurological damage and disabilities. Many people know of or heard of someone having a stroke before; it is very common in the United States. According to Centers for Disease Control and Prevention, stroke kills about 140,000 Americans each year- that’s 1 out of every 20...
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In society shopping has become a main interest involving a person's social status. The activity itself shows more about a person's relationships within society, than the products or services purchased ([2] Miller, 1998). Consumers do not just value the product or service provided when shopping, they highly value their experience in which time and money is contributing to ([3] Umesh...
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Introduction: Smallpox is a disease that attacks the skin cells, spleen, bone marrow, and lymph nodes and causes rashes, vomiting, and high fever. It is also an airborne disease which makes it especially dangerous because they tend to spread easily through coughing, sneezing, and other methods of contact with bodily fluids. 30% of infected people died within the first two...
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Aim To provide the relief from pain and care for the patients who are at the last stage of cancer, by creating spaces related to activities which a soothing effect on the inhabitants which eventually acts generate as a stress reliever. Objectives To analyse the factors that affect human and human psychology health and their influences which improves the quality...
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Emotional strain over long periods of time can inevitably lead to the final failing of relationships. Substance abuse can change the individual’s behavior, they become more isolated; closing their family and friends off. They tend to avoid family or friends who have confronted them about their addiction, and some steal from their loved ones to finance their addiction which adds...
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